Methotrexate is one of the most effective and widely used medications for treating rheumatoid arthritis ( RA) and other inflammatory types of arthritis. Side effects and dosage. Methotrexate - Maxtrex, Metoject. It is thought to affect cancer and rheumatoid arthritis by two different pathways. Methotrexate for Rheumatoid Arthritis - WebMD. Methotrexate is a drug used to treat rheumatoid arthritis, a chronic disease of the joints.
For cancer, methotrexate competitively inhibits dihydrofolate reductase ( DHFR), an enzyme that participates in the tetrahydrofolate synthesis. If you need relief from your rheumatoid arthritis, you may be interested in methotrexate. - Methotrexate elimination is reduced in patients with impaired renal functions, ascites, or pleural effusions. Such patients require especially careful monitoring for toxicity, and require dose reduction or, in some cases, discontinuation of therapy. It’ s also one of the safest arthritis drugs, insist rheumatologists, despite a common misconception among many patients and even some primary care physicians that methotrexate is highly toxic. Metotrexat artrita reumatoidă. Methotrexate is one of the most effective medications to treat rheumatoid arthritis ( RA). It' s the first drug most doctors prescribe after you’ re diagnosed. Methotrexate is an antimetabolite of the antifolate type. Pregnant women with psoriasis or rheumatoid arthritis should not receive this drug. Methotrexate works by reducing the function of the cells that are causing inflammation in the joints. Learn its side effects and how effective it is for treating RA.